Official 49ers kickoff times are shown in Pacific Time. Preseason record 2–1. Results refreshed from 49ers.com on Sept. 12, 2026. San Francisco opened the season with a 27–7 win over the Rams in Melbourne. Week 18 remains TBD.
| Week | Date | Opponent | Home/Away | Pacific | Result / TV |
|---|---|---|---|---|---|
| Pre 1 | Aug 13 | Tennessee Titans | Home | 6:00 PM | L 13–19 |
| Pre 2 | Aug 20 | Los Angeles Chargers | Away | 7:00 PM | W 41–17 |
| Pre 3 | Aug 27 | Las Vegas Raiders | Away | 5:00 PM | W 18–12 |
| 1 | Sep 10 | Los Angeles Rams | Melbourne | 5:35 PM | W 27–7 • Netflix |
| 2 | Sep 20 | Miami Dolphins | Home | 1:25 PM | FOX |
| 3 | Sep 27 | Arizona Cardinals | Home | 1:05 PM | FOX |
| 4 | Oct 4 | Denver Broncos | Home | 1:25 PM | CBS |
| 5 | Oct 11 | Seattle Seahawks | Away | 1:25 PM | FOX |
| 6 | Oct 19 | Washington Commanders | Home | 5:15 PM | ESPN / ABC |
| 7 | Oct 25 | Atlanta Falcons | Away | 10:00 AM | FOX |
| 8 | — | BYE | — | — | — |
| 9 | Nov 8 | Las Vegas Raiders | Home | 1:05 PM | CBS |
| 10 | Nov 15 | Dallas Cowboys | Away | 1:25 PM | FOX |
| 11 | Nov 22 | Minnesota Vikings | Mexico City | 5:20 PM | NBC |
| 12 | Nov 29 | Seattle Seahawks | Home | 1:25 PM | FOX |
| 13 | Dec 6 | New York Giants | Away | 10:00 AM | FOX |
| 14 | Dec 13 | Los Angeles Rams | Home | 1:25 PM | FOX |
| 15 | Dec 17 | Los Angeles Chargers | Away | 5:15 PM | Prime Video |
| 16 | Dec 27 | Kansas City Chiefs | Away | 1:25 PM | CBS |
| 17 | Jan 3 | Philadelphia Eagles | Home | 5:20 PM | NBC |
| 18 | TBD | Arizona Cardinals | Away | TBD | TBD |